INTERNATIONAL JOURNAL OF
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Quantitative evaluation by interactive image analysis system and its correlation with clinico-histopathological parameters in benign versus malignant lesions of prostate<

Author: Ekta Rani 1*, Sanjay Kumar2, Vijay Suri3, Vishal Mehrolia4

1Assitant Professor, Department of  Pathology,  Adesh institute of  medical sciences and research, Bathinda, Punjab

2Professor, Department of Pathology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana   

3Professor, Department of Pathology, Adesh institute of medical sciences and research, Bathinda, Punjab

4Medical Officer Medical Officer, Punjab civil medical services, Zira, Punjab
ABSTARCT

BACKGROUND: Morphometry is a potentially useful adjunct in surgical pathology for identifying malignant cells in lesions largely composed of benign appearing cells, distinguishing benign and malignant lesions with similar appearances or in distinguishing between similar appearing types of malignant neoplasm. The use of quantitative information on cellular details has been demonstrated to improve the accuracy and reproducibility of histopathological diagnosis. MATERIALS AND METHODS: The present study was performed on fifty cases, twenty five each of BPH and carcinoma prostate to evaluate the morphometric parameters – mean nuclear area (MNA), mean cytoplasmic area , N:C ratio , mean nuclear diameter , mean nuclear perimeter and mean nucleolar size in BPH and carcinoma prostate and its correlation with presenting symptoms and investigatory findings including- digital rectal examination , serum PSA levels , ultrasonography , histopathologic diagnosis. RESULTS: MNA ranged from 17.25-43.69 um2 (mean 26.42 ± SD 7.22) and 11.71-80.00 um2 (mean 37.15 ± SD15.17) respectively in BPH and carcinoma prostate. Mean cytoplasmic area ranged from 40.95-126.19um2 (78.34 ± SD 21.48) and 11.65-84.59um2(mean 54.60± SD 16.81) respectively in BPH and carcinoma prostate .N:C ratio in BPH and carcinoma prostate ranged from 0.18-0.69(mean 0.34 ± SD 0.11)  and 0.26-0.81um (mean 0.62± SD 0.12) respectively. Mean diameter in BPH and carcinoma prostate ranged from 1.00-2.00um (1.54 ± SD 0.29) and 1.00-2.20um (mean1.74 ±SD 0.44) respectively. Mean perimeter ranged from 4.20-8.90um (mean 6.80± SD 0.99) and 5.20-12.2um (mean8.00 ± SD 1.80) in BPH and carcinoma prostate respectively. Nucleolar size in BPH and carcinoma prostate ranged from 0.10-0.30um (mean 0.03 ± SD 0.08) and 0.04-0.40um (mean 0.13 ± SD 0.16) respectively. CONCLUSION: The variation in MNA, mean cytoplasmic area, N:C ratio mean diameter , mean perimeter and mean nucleolar size  between BPH and carcinoma prostate were statistically significant with a p value of <0.05.

Keywords: BPH, Carcinoma prostate, Morphometry, Mean nuclear area , Mean cytoplasmic area, N:C ratio, Mean diameter, mean perimeter
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